Richard Maraia
(e-mail me) Our
group investigates the molecular mechanisms involved in RNA expression in eukaryotes.
This includes
RNA synthesis by RNA polymerase III, which serves as a model system of eukaryotic
transcription, as well
as the post-transcriptional phase of RNA processing and transcript maturation.
Our goal is to understand
the mechanisms involved in these processes, their regulation, and how
they impact upon cell growth in normal
and pathological states of cellular proliferation. The
human La antigen and other key factors are central points of interest. We also
investigate the expression
of mobile Alu retroposons. These enigmatic genetic elements, which number nearly
one million copies in human DNA, use
pol III and other factors to promote their own proliferation within
our genomes.
Click here for Research Description for the NIH Graduate Partnership Program
(Inquire here about joining the Lab)
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*Role of the La antigen in mouse development
-La in tRNA Expression
-La in mRNA expression
*Transcription by RNA Polymerase III
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*Mechanisms involved in eukaryotic transcription *Transcirption Termination by RNA polymerase III *Recycling of RNA Pol III and La *Eukaryotic tRNA Expression *One of many uses of Fission Yeast in the Lab *The Alu family of retroposons *The mobile pol III promoter *3'-processing of Alu-family RNA *La and nucleo-cytoplasmic partitioning |